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Post: Interaction Of Marijuana Terpenes And Cannabinoids Offers ‘Hope’ For ‘Novel’ Treatments, Study Says

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Interaction Of Marijuana Terpenes And Cannabinoids Offers ‘Hope’ For ‘Novel’ Treatments, Study Says

A new review of the science around the components of marijuana says the “complex interaction between phytocannabinoids and biological systems offers hope for novel treatment approaches,” laying the groundwork for a new era of innovation in cannabis-based medicines.

Among other takeaways, the report, published earlier this month in the International Journal of Molecular Sciences, underscores the potential of whole-plant cannabis medicine—incorporating the variety of cannabinoids, terpenes and other compounds produced by the cannabis plant—rather than simply THC or CBD on their own.

“The plant Cannabis exhibits an effect called the ‘entourage effect’, in which the combined actions of terpenes and phytocannabinoids results in effects that exceed the sum of their separate contributions,” the study says. “This synergy emphasizes how important it is to consider the entire plant when utilizing cannabinoids medicinally as opposed to just concentrating on individual cannabinoids.”

Much of the 23-page report—from pharmacy researchers at Ovidus University of Constanta and the University of Medicine, Pharmacy Science and Technology of Târgu Mures, both of which are in Romania—comprises an overview of cannabinoids, including THC and CBD as well as cannabigerol (CBG), cannabichromene (CBC), cannabinol (CBN) and tetrahydrocannabivarin (THC-V)—as well as how those compounds appear to interact with the human body.

While the vast majority of research has studied THC and CBD, the new review notes that the “exploration of novel phytocannabinoids is rapidly evolving, offering exciting prospects for future therapeutic applications.”

“Beyond well-established compounds like THC and CBD, the quest for novel cannabinoids widens the scope of potential treatments,” it says. “Each cannabinoid, with its unique chemical structure, interacts differently with the [endocannabinoid system], suggesting tailored therapeutic effects for specific conditions. This exploration seeks to harness similar benefits while circumventing associated drawbacks.”

Each of the chemical components has specific effects, which the study briefly describes. The broad review, which cites nearly 100 other sources, acknowledges that some effects are bolstered by robust scientific evidence, while others are still being explored.

THC, for example, has demonstrated analgesic effects, authors wrote. “It also possesses antiemetic effects, which make it useful for chemotherapy-induced nausea and vomiting.”

CBD, meanwhile, has demonstrated anti-inflammatory properties and “is said to have analgesic properties […]

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