Post: Ketamine for Depression: Is There an Addiction Risk?

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Takeaway

When people use ketamine for depression under medical supervision, doctors don’t consider it highly addictive. But misuse can lead to addiction.

Ketamine was originally developed as an anesthetic in the 1960s. Its use for depression began to emerge in the early 2000s when studies showed its rapid antidepressant effects, especially in treatment-resistant depression.

Although some research indicates its effectiveness, particularly for severe and treatment-resistant depression, studies are ongoing to understand its long-term effects and addiction potential. Can ketamine be addictive when people use it for depression?

When people use ketamine under medical supervision for depression , doctors consider its risk of addiction fairly low. This is due to its controlled and monitored administration.However, ketamine does have the potential for misuse and addiction, especially when people use it recreationally or in high doses. People with a history of drug addiction may face greater risks , and the use of generic ketamine alternatives in less closely monitored settings may have a greater risk of misuse. Studies in both animals and humans suggest that repeated low dose ketamine infusions may have addictive properties and may lead to cognitive deficits. Female rodents, particularly those with high levels of ovarian hormones, seem to be more susceptible to ketamine’s addictive potential.However, it’s unclear if there’s a sex difference in humans regarding sensitivity to ketamine’s antidepressant and addictive potential. Ongoing clinical trials are expected to shed light on this issue. Additional prevention during ketamine treatments Here are some precautions your doctor may take to minimize the risk of addiction: Patient screening: Your doctor will likely conduct a thorough evaluation of your medical history, including any history of substance misuse or addiction, to determine if ketamine treatment is appropriate for you. Low doses: Doctors typically administer ketamine treatments for depression at lower doses than those used recreationally. This helps reduce the likelihood of developing a dependence on the drug. Limited frequency: Treatment sessions are usually spaced out over time to minimize the risk of developing tolerance or dependence. Medical supervision : Ketamine treatments […]

Ketamine for Depression: Is There an Addiction Risk?