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Post: Vaporized Cannabis for Acute Migraine Yields Rapid, Sustained Relief

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Vaporized Cannabis for Acute Migraine Yields Rapid, Sustained Relief


DENVER, Colorado — Vaporized cannabis containing tetrahydrocannabinol (THC) and cannabidiol (CBD) may provide rapid and sustained relief of acute migraine pain with no serious side effects, new research suggests.

"In this single center randomized controlled trial across 247 treated migraine attacks, 4 puffs of vaporized THC-CBD mix were efficacious for acute migraine treatment," said study investigator Nathaniel Marc Schuster, MD, with University of California San Diego Center for Pain Medicine.

The superiority of THC-CBD over placebo was "unlikely explained by unmasking given that in our blinding analysis most patients who got THC actually did not think they got some THC," Schuster said.

He presented the results (Abstract S22.010) on April 16 at the American Academy of Neurology (AAN) 2024 annual meeting. Sustained Pain Relief

Preclinical and retrospective studies point to antimigraine effects of cannabinoids, yet strong evidence of efficacy from a randomized controlled trial has been lacking.

The researchers tested the efficacy of cannabis for acute migraine in what they report is the first randomized, double-blind, placebo-controlled, crossover trial of adults with migraine.Participants treated up to four separate moderate to severe migraine attacks, each with one of four different treatments. The four treatments were: 6% THC, 11% CBD, a mix of 6% THC and 11% CBD, or placebo flower from the National Institute on Drug Abuse that has a similar taste and smell to the other products.The four treatments were vaporized in a randomized order, with at least 1 week washout between treatments. The primary endpoint was pain relief at 2 […]

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