A person using tweezers to handle tiny drug strips on their fingertip, symbolizing the concept of microdosing LSD for controlled substance intake. Read time: 3 minutes
The perceived benefits of microdosing for attention-deficit/hyperactivity disorder (ADHD) may stem more from expectation than from actual pharmacological effects. That’s according to a new study from the University Hospital Basel in Switzerland and Maastricht University in the Netherlands, published in JAMA Psychiatry . Understanding ADHD and challenges in treatment
ADHD is a common neurodevelopmental disorder affecting ~2.6% of adults worldwide . It is characterized by symptoms of inattention, hyperactivity and impulsivity, impairing daily functioning, occupational performance and overall quality of life. While pharmacological medications categorized as stimulants and nonstimulants are the standard of care, they are not universally effective. Studies indicate that up to 40% of patients do not achieve adequate symptom control, and many experience adverse effects that can lead to medication discontinuation.
Given these challenges, there is a growing interest in exploring alternative treatments for ADHD, including psychedelic microdosing. Want more breaking news?
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Microdosing refers to the practice of taking small doses of psychedelics, such as lysergic acid diethylamide (LSD) or psilocybin , with the intention of enhancing cognitive function or alleviating psychiatric symptoms without inducing psychoactive effects. Typically, a microdose of LSD ranges from 5 to 20 µg, and users often follow a regimen of dosing every few days over several weeks. Anecdotal reports and naturalistic studies have suggested that microdosing LSD may alleviate symptoms of ADHD, including inattention and impulsivity, but controlled clinical evidence remains sparse. Naturalistic studies
Research conducted in real-world settings without experimental manipulation, often relying on observational data and self-reported outcomes.
Most evidence supporting microdosing for ADHD comes from self-reported improvements and observational data, lacking the rigorous controls necessary to establish causal relationships. A recent systematic review of microdosing studies emphasized the need for randomized controlled trials to validate claims of efficacy.In an effort to explore whether microdosing LSD could improve symptoms of ADHD, researchers conducted a […]
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