Summary: Researchers used machine learning to identify three subtypes of Parkinson’s disease based on progression speed. These subtypes, marked by distinct genetic drivers, could enhance diagnosis and treatment strategies.
The study also found that the diabetes drug metformin might improve symptoms, especially in the rapidly progressing subtype. The findings pave the way for personalized treatment approaches for Parkinson’s patients.
Key Facts:
> Three Subtypes: Parkinson’s subtypes defined by progression speed: Inching Pace, Moderate Pace, and Rapid Pace.
Distinct Drivers: Each subtype has unique genetic and molecular markers.
Potential Treatment: Metformin shows promise in improving symptoms, particularly in the Rapid Pace subtype.
Source: Weill Cornell University
Researchers at Weill Cornell Medicine have used machine learning to define three subtypes of Parkinson’s disease based on the pace at which the disease progresses.
In addition to having the potential to become an important diagnostic and prognostic tool, these subtypes are marked by distinct driver genes. If validated, these markers could also suggest ways the subtypes can be targeted with new and existing drugs. The researchers used their findings to identify possible drug candidates that could be repurposed to target the specific molecular changes seen in the different subtypes. Credit: Neuroscience News The research was published on July 10 in npj Digital Medicine. “Parkinson’s disease is highly heterogeneous, which means that people with the same disease can have very different symptoms,” said senior author Dr. Fei Wang, a professor of population health sciences and the founding director of the Institute of AI for Digital Health (AIDH) in the Department of Population Health Sciences at Weill Cornell Medicine.“This indicates there is not likely to be a one-size-fits-all approach to treating it. We may need to consider customized treatment strategies based on a patient’s disease subtype.”The investigators defined the subtypes based on their distinct patterns of disease progression. They named them the Inching Pace subtype (PD-I, about 36% of patients) for disease with a mild baseline severity and mild progression speed, the Moderate Pace subtype (PD-M, about 51% of patients) for cases that have mild baseline severity but advance at a moderate rate, and Rapid Pace […]
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