Close-up of cannabis plants with green and yellow leaves, representing the discussion around cannabis use disorder and its effects. Read time: 2 minutes
Cannabis remains one of the most widely consumed psychoactive substances globally, with an estimated 228 million users aged 15 to 64. Its use is associated with a heightened risk of developing schizophrenia, particularly when initiated at a young age. An estimated 10% of users will develop cannabis use disorder (CUD) during their lifetime, while CUD affects up to 42% of individuals with schizophrenia. Cannabis use disorder (CUD)
Cannabis use disorder is a medical condition characterized by the problematic use of cannabis, resulting in significant impairment or distress. Symptoms include cravings, increased tolerance, withdrawal symptoms and difficulty controlling use despite adverse consequences.
To explore the biological basis behind why some cannabis users develop schizophrenia and others only CUD, researchers from the Neuropsychopharmacology group at the University of the Basque Country (UPV/EHU) conducted a study examining blood-based biomarkers. The team sought to identify early indicators that could signal a heightened risk of schizophrenia in cannabis users, with findings published in Scientific Reports . Want more breaking news?
Subscribe for FREE Investigating fatty acid profiles
The study analyzed blood samples from four distinct groups: individuals with schizophrenia who did not use cannabis; cannabis users with CUD; individuals with both schizophrenia and CUD; and a control group without psychiatric or substance use disorders. Using lipidomics, the researchers examined differences in fatty acid metabolites across the groups. Lipidomics
Lipidomics is the study of cellular lipid pathways, including how lipids are produced, modified and degraded in biological systems. This field uses analytical techniques like mass spectrometry to profile lipid molecules, providing insights into disease mechanisms and biomarker discovery. Fatty acids
Fatty acids are long-chain hydrocarbons that are important components of lipids in the body. They play key roles in energy storage, cell membrane structure and signaling pathways. Alterations in fatty acid metabolism are linked to various diseases, including mental health conditions. Lipid biomarkers
Lipid biomarkers are molecules found in the blood or other tissues that reflect changes in lipid […]
Cannabis Use Alters Fatty Acid Metabolism Linked to Schizophrenia Risk
