Tryptamine is pioneering delivery of psychedelic medicines through IV infusion. Pic: Getty Images Tryptamine is developing an IV-infused psilocin solution to be used with psychotherapy for unmet medical needs
Solution addresses current limitations associated with orally administered psilocybin
The company is targeting binge eating disorder, fibromyalgia and irritable bowel syndrome
Special Report : Clinical-stage biotech Tryptamine Therapeutics (ASX:TYP) is pioneering a precision approach to psychedelics, targeting precise drug blood levels in patients to minimise the risk of side effects, while maximising the benefits of treatment.
Interest in the emerging field of psilocybin – the active ingredient in magic mushrooms – has grown in recent years with various research demonstrating that psychedelics-assisted therapy holds great promise for helping people with a range of existing treatment-resistant conditions.
TYP became part of the Aussie bourse in May after Exopharm acquired Canadian-based Tryp Therapeutics and rebranded as Tryptamine Therapeutics.
CEO Jason Carroll says the company’s lead program TRP-8803 is an IV-infusion of psilocin addressing many of the current limitations associated with orally administered psilocybin used by most competitors in the field.
“When you take an oral capsule of psilocybin it has to go through the liver as every drug does when you take it orally, which is called first pass metabolism,” explains Carroll
He says after being metabolised by the liver, psilocin – the active metabolite of psilocybin – can have different effects on people.“It can depend on how effective someone’s liver is, so the amount of psilocin the brain gets from a person with a fast metabolism may not be enough.“For a person with a slow metabolism their brain may get more psilocin than they need.”Carroll notes that research shows there can be a fourfold difference between the blood levels of psilocin for every patient:“So, if you get four patients there can be four different levels of psilocin in their blood so you can get four different responses. So, some won’t get an effect and some will get a strong effect including a lot of side effects.” Precision approach through IV-infused psilocin Carroll says for patients to all get the same dose […]
How Tryptamine is pioneering precision psychedelic treatment
