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Post: Adderall Alternatives; Alcohol Use Disorder Nasal Spray? Matthew Perry Fellowship

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Adderall Alternatives; Alcohol Use Disorder Nasal Spray? Matthew Perry Fellowship
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Illustration of a brain shaped maze. A study suggested that a shortage of immediate-release mixed amphetamine salts (Adderall) to treat attention deficit-hyperactivity disorderopens in a new tab or window (ADHD) may have prompted a switch to alternative stimulants for kids. ( Pediatrics )

From 2013 to 2024, the FDA approved 16 novel drugsopens in a new tab or window to treat psychiatric diseases — three of which had more negative or failed efficacy trials than positive ones, including one antidepressantopens in a new tab or window that was approved based on two positive trials but had 10 other failed trials, a cross-sectional study showed. ( JAMA Network Open )

Combined with relapse prevention therapy, an intranasal formulation of 5-MeO-DMT benzoate reduced the average number of alcohol units consumedopens in a new tab or window per day, from 9.3 to 2.2 units by week 12, in a phase IIa study, said developer atai Life Sciences.

The FDA approved a monthly maintenance dose of intravenous lecanemab (Leqembi) for early Alzheimer’s diseaseopens in a new tab or window , drugmakers Eisai and Biogen announced.

Pregnant people exposed to acute heatwave periods in North Carolina had a 13% higher risk of severe mental illnessopens in a new tab or window , while prolonged exposure to moderate-intensity heatwaves was tied to a 37% higher risk, according to a matched analysis. ( The Lancet Regional Health Americas )

A Department of Labor investigation on insurance coverage of mental health careopens in a new tab or window revealed broad noncompliance and an "alarming" rate of ghost networks. ( ProPublica )

Massachusetts General Hospital in Boston announced the creation of the Matthew Perry Foundation Fellowship in Addiction Medicineopens in a new tab or window .

Since 2001, there has been a threefold to fivefold increase in the prevalence of sedative, hypnotic, or anxiolytic use disordersopens in a new tab or window among adolescent and young adult Medicaid enrollees, a cross-sectional study showed. ( Addiction )

Men and women with ADHD died 6.8 years and 8.6 years earlieropens in a new tab or window than the general population, a matched cohort study from the U.K. suggested. […]

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